Acyclovir vs Methotrexate

## Acyclovir vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Acyclovir** and **Methotrexate**.

## Mechanism of Action

**Acyclovir**: Guanosine analogue inhibiting viral DNA polymerase.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Acyclovir — 2.5-3.3 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Acyclovir — C8H11N5O3; Methotrexate — C20H22N8O5.

**Molecular Weight**: Acyclovir — 225.2050 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Acyclovir — Small molecule; Methotrexate — Small molecule.