Afatinib vs Loratadine

## Afatinib vs Loratadine: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Loratadine**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Loratadine — 8 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Loratadine — C22H23ClN2O2.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Loratadine — 382.8800 g/mol.

**Type**: Afatinib — Small molecule; Loratadine — Small molecule.