Amlodipine vs Hydrochlorothiazide

## Amlodipine vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Amlodipine** and **Hydrochlorothiazide**.

## Mechanism of Action

**Amlodipine**: Dihydropyridine calcium channel blocker.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Amlodipine — 30-50 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Amlodipine — C20H25ClN2O5; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Amlodipine — 408.8800 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Amlodipine — Small molecule; Hydrochlorothiazide — Small molecule.