Aspirin vs Tofacitinib

## Aspirin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Aspirin** and **Tofacitinib**.

## Mechanism of Action

**Aspirin**: Irreversibly inhibits cyclooxygenase-1 and -2.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Aspirin — 2-3 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Aspirin — C9H8O4; Tofacitinib — C16H20N6O.

**Molecular Weight**: Aspirin — 180.1580 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Aspirin — Small molecule; Tofacitinib — Small molecule.