Atezolizumab vs Nivolumab

## Atezolizumab vs Nivolumab: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Nivolumab**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Nivolumab**: Fully human anti-PD-1 IgG4 monoclonal antibody restoring T-cell anti-tumor activity.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Nivolumab — 27 days.

## Chemical Properties

**Type**: Atezolizumab — Antibody; Nivolumab — Antibody.