Baricitinib vs Tofacitinib

## Baricitinib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Baricitinib** and **Tofacitinib**.

## Mechanism of Action

**Baricitinib**: Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Baricitinib — 12 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Baricitinib — C16H17N7O2S; Tofacitinib — C16H20N6O.

**Molecular Weight**: Baricitinib — 371.4170 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Baricitinib — Small molecule; Tofacitinib — Small molecule.