Buprenorphine vs Fentanyl

## Buprenorphine vs Fentanyl: Overview

This comparison examines the pharmacological differences between **Buprenorphine** and **Fentanyl**.

## Mechanism of Action

**Buprenorphine**: Partial mu-opioid receptor agonist and kappa antagonist with high receptor affinity.

**Fentanyl**: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

## Pharmacokinetics

**Half-life**: Buprenorphine — 24-42 hours; Fentanyl — 2-4 hours.

## Chemical Properties

**Molecular Formula**: Buprenorphine — C29H41NO4; Fentanyl — C22H28N2O.

**Molecular Weight**: Buprenorphine — 467.6430 g/mol; Fentanyl — 336.4700 g/mol.

**Type**: Buprenorphine — Small molecule; Fentanyl — Small molecule.