Captopril vs Erlotinib

## Captopril vs Erlotinib: Overview

This comparison examines the pharmacological differences between **Captopril** and **Erlotinib**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Erlotinib**: Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Erlotinib — 36 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Erlotinib — C22H23N3O4.

**Molecular Weight**: Captopril — 217.2850 g/mol; Erlotinib — 393.4380 g/mol.

**Type**: Captopril — Small molecule; Erlotinib — Small molecule.