Captopril vs Metformin

## Captopril vs Metformin: Overview

This comparison examines the pharmacological differences between **Captopril** and **Metformin**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Metformin — 4-9 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Metformin — C4H11N5.

**Molecular Weight**: Captopril — 217.2850 g/mol; Metformin — 129.1640 g/mol.

**Type**: Captopril — Small molecule; Metformin — Small molecule.