Captopril vs Methotrexate

## Captopril vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Captopril** and **Methotrexate**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Methotrexate — C20H22N8O5.

**Molecular Weight**: Captopril — 217.2850 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Captopril — Small molecule; Methotrexate — Small molecule.