Captopril vs Simvastatin

## Captopril vs Simvastatin: Overview

This comparison examines the pharmacological differences between **Captopril** and **Simvastatin**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Simvastatin — 2 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Simvastatin — C25H38O5.

**Molecular Weight**: Captopril — 217.2850 g/mol; Simvastatin — 418.5700 g/mol.

**Type**: Captopril — Small molecule; Simvastatin — Small molecule.