Dapagliflozin vs Tofacitinib

## Dapagliflozin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Dapagliflozin** and **Tofacitinib**.

## Mechanism of Action

**Dapagliflozin**: Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Dapagliflozin — 12.9 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Dapagliflozin — C21H25ClO6; Tofacitinib — C16H20N6O.

**Molecular Weight**: Dapagliflozin — 408.8730 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Dapagliflozin — Small molecule; Tofacitinib — Small molecule.