Diazepam vs Diphenhydramine

## Diazepam vs Diphenhydramine: Overview

This comparison examines the pharmacological differences between **Diazepam** and **Diphenhydramine**.

## Mechanism of Action

**Diazepam**: Positive allosteric modulator of GABA-A receptors.

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

## Pharmacokinetics

**Half-life**: Diazepam — 20-100 hours; Diphenhydramine — 2-8 hours.

## Chemical Properties

**Molecular Formula**: Diazepam — C16H13ClN2O; Diphenhydramine — C17H21NO.

**Molecular Weight**: Diazepam — 284.7400 g/mol; Diphenhydramine — 255.3550 g/mol.

**Type**: Diazepam — Small molecule; Diphenhydramine — Small molecule.