Digoxin vs Methotrexate

## Digoxin vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Digoxin** and **Methotrexate**.

## Mechanism of Action

**Digoxin**: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Digoxin — 36-48 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Digoxin — C41H64O14; Methotrexate — C20H22N8O5.

**Molecular Weight**: Digoxin — 780.9430 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Digoxin — Small molecule; Methotrexate — Small molecule.