Diphenhydramine vs Gabapentin

## Diphenhydramine vs Gabapentin: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Gabapentin**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Gabapentin**: Binds alpha-2-delta subunit of voltage-gated calcium channels.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Gabapentin — 5-7 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Gabapentin — C9H17NO2.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Gabapentin — 171.2370 g/mol.

**Type**: Diphenhydramine — Small molecule; Gabapentin — Small molecule.