Diphenhydramine vs Spironolactone

## Diphenhydramine vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Spironolactone**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Spironolactone — C24H32O4S.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Diphenhydramine — Small molecule; Spironolactone — Small molecule.