Duloxetine vs Sertraline

## Duloxetine vs Sertraline: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Sertraline**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Sertraline**: Selective serotonin reuptake inhibitor (SSRI).

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Sertraline — 26 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Sertraline — C17H17Cl2N.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Sertraline — 306.2290 g/mol.

**Type**: Duloxetine — Small molecule; Sertraline — Small molecule.