Duloxetine vs Sildenafil

## Duloxetine vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Sildenafil**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Duloxetine — Small molecule; Sildenafil — Small molecule.