Durvalumab vs Hydrochlorothiazide

## Durvalumab vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Durvalumab** and **Hydrochlorothiazide**.

## Mechanism of Action

**Durvalumab**: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Durvalumab — 17 days; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Durvalumab — N/A; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Durvalumab — N/A; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Durvalumab — Antibody; Hydrochlorothiazide — Small molecule.