Durvalumab vs Hydroxychloroquine

## Durvalumab vs Hydroxychloroquine: Overview

This comparison examines the pharmacological differences between **Durvalumab** and **Hydroxychloroquine**.

## Mechanism of Action

**Durvalumab**: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

**Hydroxychloroquine**: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

## Pharmacokinetics

**Half-life**: Durvalumab — 17 days; Hydroxychloroquine — 40-50 days.

## Chemical Properties

**Molecular Formula**: Durvalumab — N/A; Hydroxychloroquine — C18H26ClN3O.

**Molecular Weight**: Durvalumab — N/A; Hydroxychloroquine — 335.8720 g/mol.

**Type**: Durvalumab — Antibody; Hydroxychloroquine — Small molecule.