Durvalumab vs Tacrolimus

## Durvalumab vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Durvalumab** and **Tacrolimus**.

## Mechanism of Action

**Durvalumab**: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Durvalumab — 17 days; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Durvalumab — N/A; Tacrolimus — C44H69NO12.

**Molecular Weight**: Durvalumab — N/A; Tacrolimus — 804.0180 g/mol.

**Type**: Durvalumab — Antibody; Tacrolimus — Small molecule.