Hydroxychloroquine vs Trimethoprim

## Hydroxychloroquine vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Hydroxychloroquine** and **Trimethoprim**.

## Mechanism of Action

**Hydroxychloroquine**: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Hydroxychloroquine — 40-50 days; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Hydroxychloroquine — C18H26ClN3O; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Hydroxychloroquine — 335.8720 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Hydroxychloroquine — Small molecule; Trimethoprim — Small molecule.