Ibuprofen vs Methotrexate

## Ibuprofen vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Ibuprofen** and **Methotrexate**.

## Mechanism of Action

**Ibuprofen**: Non-selective COX inhibitor reducing prostaglandin synthesis.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Ibuprofen — 2-4 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Ibuprofen — C13H18O2; Methotrexate — C20H22N8O5.

**Molecular Weight**: Ibuprofen — 206.2810 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Ibuprofen — Small molecule; Methotrexate — Small molecule.