Ibuprofen vs Tofacitinib

## Ibuprofen vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Ibuprofen** and **Tofacitinib**.

## Mechanism of Action

**Ibuprofen**: Non-selective COX inhibitor reducing prostaglandin synthesis.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Ibuprofen — 2-4 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Ibuprofen — C13H18O2; Tofacitinib — C16H20N6O.

**Molecular Weight**: Ibuprofen — 206.2810 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Ibuprofen — Small molecule; Tofacitinib — Small molecule.