Ipilimumab vs Upadacitinib

## Ipilimumab vs Upadacitinib: Overview

This comparison examines the pharmacological differences between **Ipilimumab** and **Upadacitinib**.

## Mechanism of Action

**Ipilimumab**: Fully human anti-CTLA-4 IgG1 monoclonal antibody that blocks CTLA-4 inhibitory signaling.

**Upadacitinib**: Selective JAK1 inhibitor reducing signaling from cytokines implicated in autoimmune diseases.

## Pharmacokinetics

**Half-life**: Ipilimumab — 14.7 days; Upadacitinib — 9-14 hours.

## Chemical Properties

**Molecular Formula**: Ipilimumab — N/A; Upadacitinib — C17H19F3N6O.

**Molecular Weight**: Ipilimumab — N/A; Upadacitinib — 380.3700 g/mol.

**Type**: Ipilimumab — Antibody; Upadacitinib — Small molecule.