Loratadine vs Methotrexate

## Loratadine vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Methotrexate**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Methotrexate — C20H22N8O5.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Loratadine — Small molecule; Methotrexate — Small molecule.