Loratadine vs Montelukast

## Loratadine vs Montelukast: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Montelukast**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Montelukast**: Selective leukotriene D4 receptor antagonist.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Montelukast — 2.7-5.5 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Montelukast — C35H36ClNO3S.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Montelukast — 586.1800 g/mol.

**Type**: Loratadine — Small molecule; Montelukast — Small molecule.