Loratadine vs Paroxetine

## Loratadine vs Paroxetine: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Paroxetine**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Paroxetine**: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Paroxetine — 21 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Paroxetine — C19H20FNO3.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Paroxetine — 329.3730 g/mol.

**Type**: Loratadine — Small molecule; Paroxetine — Small molecule.