Losartan vs Sacubitril-Valsartan

## Losartan vs Sacubitril-Valsartan: Overview

This comparison examines the pharmacological differences between **Losartan** and **Sacubitril-Valsartan**.

## Mechanism of Action

**Losartan**: Angiotensin II receptor type 1 antagonist.

**Sacubitril-Valsartan**: Angiotensin receptor-neprilysin inhibitor (ARNI) combining neprilysin inhibition with AT1 receptor blockade.

## Pharmacokinetics

**Half-life**: Losartan — 2 hours; Sacubitril-Valsartan — 11.5 hours.

## Chemical Properties

**Molecular Formula**: Losartan — C22H23ClN6O; Sacubitril-Valsartan — C24H29N2O5.

**Molecular Weight**: Losartan — 422.9200 g/mol; Sacubitril-Valsartan — 414.5010 g/mol.

**Type**: Losartan — Small molecule; Sacubitril-Valsartan — Small molecule.