Lovastatin vs Simvastatin

## Lovastatin vs Simvastatin: Overview

This comparison examines the pharmacological differences between **Lovastatin** and **Simvastatin**.

## Mechanism of Action

**Lovastatin**: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Lovastatin — 2-3 hours; Simvastatin — 2 hours.

## Chemical Properties

**Molecular Formula**: Lovastatin — C24H36O5; Simvastatin — C25H38O5.

**Molecular Weight**: Lovastatin — 404.5390 g/mol; Simvastatin — 418.5700 g/mol.

**Type**: Lovastatin — Small molecule; Simvastatin — Small molecule.