Metformin vs Simvastatin

## Metformin vs Simvastatin: Overview

This comparison examines the pharmacological differences between **Metformin** and **Simvastatin**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Simvastatin — 2 hours.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Simvastatin — C25H38O5.

**Molecular Weight**: Metformin — 129.1640 g/mol; Simvastatin — 418.5700 g/mol.

**Type**: Metformin — Small molecule; Simvastatin — Small molecule.