Metformin vs Tofacitinib

## Metformin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Metformin** and **Tofacitinib**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Metformin — 129.1640 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Metformin — Small molecule; Tofacitinib — Small molecule.