Methotrexate vs Rituximab

## Methotrexate vs Rituximab: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Rituximab**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Rituximab**: Chimeric anti-CD20 IgG1 monoclonal antibody inducing B-cell depletion via CDC, ADCC, and apoptosis.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Rituximab — 22 days.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Rituximab — N/A.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Rituximab — N/A.

**Type**: Methotrexate — Small molecule; Rituximab — Antibody.