Methotrexate vs Tofacitinib

## Methotrexate vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Tofacitinib**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Methotrexate — Small molecule; Tofacitinib — Small molecule.