Tacrolimus vs Trimethoprim

## Tacrolimus vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Tacrolimus** and **Trimethoprim**.

## Mechanism of Action

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Tacrolimus — 12 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Tacrolimus — C44H69NO12; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Tacrolimus — 804.0180 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Tacrolimus — Small molecule; Trimethoprim — Small molecule.