Tamoxifen vs Tofacitinib

## Tamoxifen vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Tamoxifen** and **Tofacitinib**.

## Mechanism of Action

**Tamoxifen**: Selective estrogen receptor modulator (SERM).

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Tamoxifen — 5-7 days; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Tamoxifen — C26H29NO; Tofacitinib — C16H20N6O.

**Molecular Weight**: Tamoxifen — 371.5150 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Tamoxifen — Small molecule; Tofacitinib — Small molecule.