Tofacitinib vs Trimethoprim

## Tofacitinib vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Tofacitinib** and **Trimethoprim**.

## Mechanism of Action

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Tofacitinib — 3.2 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Tofacitinib — C16H20N6O; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Tofacitinib — 312.3700 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Tofacitinib — Small molecule; Trimethoprim — Small molecule.