Apalutamide

CHEMBL3183409 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

477.4 g/mol

LogP

3.0

Phase

4

A next-generation androgen receptor inhibitor that blocks the effects of testosterone and other male hormones on prostate cancer cells, slowing their growth and spread. It is approved for non-metastatic and metastatic castration-resistant prostate cancer.

الوزن الجزيئي

477,4000 g/mol

LogP

3,00

TPSA

121,00 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

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SMILES

CNC(=O)c1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F

InChI

InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

Molecular Formula

C21H15F4N5O2S

HBD / HBA

1 / 9

الروابط القابلة للدوران

3

الذرات الثقيلة

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A next-generation androgen receptor inhibitor that blocks the effects of testosterone and other male hormones on prostate cancer cells, slowing their growth and spread. It is approved for non-metastatic and metastatic castration-resistant prostate cancer.

Yes, Apalutamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3183409. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 24872560. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C21H15F4N5O2S
المرادفات: 1

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.