Asenapine Maleate

CHEMBL3544974 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

401.8 g/mol

LogP

—

Phase

4

The maleate salt of asenapine, formulated as a sublingual tablet or skin patch that delivers this antipsychotic by avoiding the gastrointestinal tract. It is used in the management of schizophrenia and acute manic or mixed episodes of bipolar disorder.

الوزن الجزيئي

401,8000 g/mol

TPSA

87,10 Å²

المجالات العلاجية

Schizophrenia Bipolar Disorder Gastroesophageal Reflux Disease Stroke Major Depressive Disorder

آلية العمل

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal …

البنية ثنائية الأبعاد

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SMILES

CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1.O=C(O)/C=C\C(=O)O

InChI

InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Molecular Formula

C21H20ClNO5

HBD / HBA

2 / 6

الروابط القابلة للدوران

2

الذرات الثقيلة

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

The maleate salt of asenapine, formulated as a sublingual tablet or skin patch that delivers this antipsychotic by avoiding the gastrointestinal tract. It is used in the management of schizophrenia and acute manic or mixed episodes of bipolar disorder.

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Yes, Asenapine Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3544974. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6917875. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C21H20ClNO5
المرادفات: 2

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.