Avatrombopag
A thrombopoietin receptor agonist that stimulates the bone marrow to produce more platelets by mimicking the action of thrombopoietin. It is used to increase platelet counts before procedures in patients with chronic liver disease who have low platelets.
الوزن الجزيئي
649,7000 g/mol
LogP
4,00
TPSA
158,00 Ų
قاعدة ليبينسكي للخمسة
ناجح
المجالات العلاجية
آلية العمل
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
O=C(Nc1nc(-c2cc(Cl)cs2)c(N2CCN(C3CCCCC3)CC2)s1)c1cnc(N2CCC(C(=O)O)CC2)c(Cl)c1
InChI
InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
Molecular Formula
C29H34Cl2N6O3S2
HBD / HBA
2 / 10
الروابط القابلة للدوران
7
الذرات الثقيلة
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
A thrombopoietin receptor agonist that stimulates the bone marrow to produce more platelets by mimicking the action of thrombopoietin. It is used to increase platelet counts before procedures in patients with chronic liver disease who have low platelets.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Avatrombopag is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103883. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9852519. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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