Baricitinib
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
الوزن الجزيئي
371,4170 g/mol
LogP
-0,50
TPSA
129,00 Ų
قاعدة ليبينسكي للخمسة
ناجح
المجالات العلاجية
تصنيفات الأدوية
آلية العمل
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1
InChI
InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
Molecular Formula
C16H17N7O2S
HBD / HBA
1 / 7
الروابط القابلة للدوران
5
الذرات الثقيلة
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Key pharmacokinetic parameters for Baricitinib: Half-life: 12 hours.
Yes, Baricitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105759. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44205240. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="baricitinib"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/baricitinib/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/baricitinib/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/baricitinib/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="baricitinib"></drugfyi-drug>