Belinostat

CHEMBL408513 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

318.3 g/mol

LogP

1.7

Phase

4

A histone deacetylase (HDAC) inhibitor that alters gene expression in cancer cells by preventing the removal of acetyl groups from histones, reactivating tumor suppressor genes and promoting cancer cell death. It is approved for relapsed or refractory peripheral T-cell lymphoma.

الوزن الجزيئي

318,3000 g/mol

LogP

1,70

TPSA

104,00 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

O=C(/C=C/c1cccc(S(=O)(=O)Nc2ccccc2)c1)NO

InChI

InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

Molecular Formula

C15H14N2O4S

HBD / HBA

3 / 5

الروابط القابلة للدوران

5

الذرات الثقيلة

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A histone deacetylase (HDAC) inhibitor that alters gene expression in cancer cells by preventing the removal of acetyl groups from histones, reactivating tumor suppressor genes and promoting cancer cell death. It is approved for relapsed or refractory peripheral T-cell lymphoma.

Yes, Belinostat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL408513. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6918638. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C15H14N2O4S
المرادفات: 1

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.