Brinzolamide
A carbonic anhydrase inhibitor used as eye drops to lower elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor inside the eye. It is often used in combination with other eye pressure-lowering drops.
الوزن الجزيئي
383,5000 g/mol
LogP
-0,30
TPSA
164,00 Ų
قاعدة ليبينسكي للخمسة
ناجح
المجالات العلاجية
آلية العمل
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
InChI
InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
Molecular Formula
C12H21N3O5S3
HBD / HBA
2 / 9
الروابط القابلة للدوران
7
الذرات الثقيلة
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
A carbonic anhydrase inhibitor used as eye drops to lower elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor inside the eye. It is often used in combination with other eye pressure-lowering drops.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Brinzolamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL220491. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 68844. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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