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Buspirone

CHEMBL49 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
385.5 g/mol
LogP
2.6
Phase
4

A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.

الوزن الجزيئي

385,5000 g/mol

LogP

2,60

TPSA

69,60 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Parkinson's Disease Epilepsy Schizophrenia Generalized Anxiety Disorder Gastroesophageal Reflux Disease Stroke Major Depressive Disorder Heart Failure

آلية العمل

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …

البنية ثنائية الأبعاد

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Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H31N5O2

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
الروابط القابلة للدوران

                        
6

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Buspirone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL49.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2477.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.