Capmatinib Hydrochloride

CHEMBL3989937 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

503.4 g/mol

LogP

—

Phase

4

The hydrochloride salt form of capmatinib, a selective MET inhibitor used for metastatic non-small cell lung cancer with MET exon 14 skipping mutations. It is taken orally twice daily and demonstrates meaningful responses in this molecularly defined patient group. Photosensitivity reactions require patients to avoid excessive sun exposure during treatment.

الوزن الجزيئي

503,4000 g/mol

TPSA

86,10 Å²

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

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SMILES

CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F.Cl.Cl.O

InChI

InChI=1S/C23H17FN6O.2ClH.H2O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20;;;/h2-9,11-13H,10H2,1H3,(H,25,31);2*1H;1H2

Molecular Formula

C23H21Cl2FN6O2

HBD / HBA

4 / 7

الروابط القابلة للدوران

4

الذرات الثقيلة

34

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

The hydrochloride salt form of capmatinib, a selective MET inhibitor used for metastatic non-small cell lung cancer with MET exon 14 skipping mutations. It is taken orally twice daily and demonstrates meaningful responses in this molecularly defined patient group. Photosensitivity reactions require patients to avoid excessive sun exposure during treatment.

Yes, Capmatinib Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989937. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 122201352. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C23H21Cl2FN6O2

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.