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Diphenhydramine Hydrochloride

CHEMBL1620 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
291.8 g/mol
LogP
—
Phase
4

The hydrochloride salt form of diphenhydramine, the most widely used pharmaceutical form found in oral tablets, capsules, liquid preparations, and topical formulations. It provides the same antihistamine, sedative, and anticholinergic effects as the parent compound. It is the active ingredient in many over-the-counter sleep aids and allergy medications.

الوزن الجزيئي

291,8000 g/mol

TPSA

12,50 Ų

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Cardiovascular Disease Respiratory Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Infectious Disease Melanoma Oncology Gastroesophageal Reflux Disease Inflammatory Bowel Disease Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Lymphoma Hypertension Major Depressive Disorder Breast Cancer Atopic Dermatitis Gout Chronic Pain Prostate Cancer Colorectal Cancer Leukemia

آلية العمل

First-generation H1 antihistamine with anticholinergic properties.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

First-generation H1 antihistamine with anticholinergic properties.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN(C)CCOC(c1ccccc1)c1ccccc1.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H22ClNO

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
الروابط القابلة للدوران

                        
6

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
The hydrochloride salt form of diphenhydramine, the most widely used pharmaceutical form found in oral tablets, capsules, liquid preparations, and topical formulations. It provides the same antihistamine, sedative, and anticholinergic effects as the parent compound. It is the active ingredient in many over-the-counter sleep aids and allergy medications.

                        

                    

                    

                    

                    
                    

                        
                        

                            
First-generation H1 antihistamine with anticholinergic properties.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Diphenhydramine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1620.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 8980.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.