Glasdegib
A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.
الوزن الجزيئي
374,4000 g/mol
LogP
2,40
TPSA
96,80 Ų
قاعدة ليبينسكي للخمسة
ناجح
المجالات العلاجية
Pharmacokinetics (PK)
Pharmacodynamics (PD)
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
CN1CC[C@@H](NC(=O)Nc2ccc(C#N)cc2)C[C@@H]1c1nc2ccccc2[nH]1
InChI
InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
Molecular Formula
C21H22N6O
HBD / HBA
3 / 4
الروابط القابلة للدوران
3
الذرات الثقيلة
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.
Yes, Glasdegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2043437. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25166913. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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