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Idelalisib

CHEMBL2216870 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
415.4 g/mol
LogP
3.7
Phase
4

This oral targeted therapy inhibits phosphoinositide 3-kinase delta (PI3Kδ), an enzyme involved in the survival, proliferation, and migration of malignant B-cells. It is used to treat relapsed chronic lymphocytic leukemia (CLL) and follicular lymphoma. Serious side effects including liver toxicity, diarrhea, pneumonia, and infections require close monitoring.

الوزن الجزيئي

415,4000 g/mol

LogP

3,70

TPSA

99,20 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Pancreatic Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H18FN7O

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
الروابط القابلة للدوران

                        
5

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
31

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
This oral targeted therapy inhibits phosphoinositide 3-kinase delta (PI3Kδ), an enzyme involved in the survival, proliferation, and migration of malignant B-cells. It is used to treat relapsed chronic lymphocytic leukemia (CLL) and follicular lymphoma. Serious side effects including liver toxicity, diarrhea, pneumonia, and infections require close monitoring.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Idelalisib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2216870.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11625818.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.