Ivacaftor

CHEMBL2010601 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

392.5 g/mol

LogP

5.6

Phase

4

This CFTR potentiator is used to treat cystic fibrosis in patients with specific mutations (such as G551D) that cause the CFTR protein to be present but dysfunctional. It works by binding to the abnormal CFTR protein and keeping its chloride channel open for longer, improving airway hydration and mucus clearance. It was the first therapy to target the underlying genetic defect in cystic fibrosis.

الوزن الجزيئي

392,5000 g/mol

LogP

5,60

TPSA

78,40 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Chronic Obstructive Pulmonary Disease Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure

Embed this structure

SMILES

CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O

InChI

InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)

Molecular Formula

C24H28N2O3

HBD / HBA

3 / 4

الروابط القابلة للدوران

4

الذرات الثقيلة

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

This CFTR potentiator is used to treat cystic fibrosis in patients with specific mutations (such as G551D) that cause the CFTR protein to be present but dysfunctional. It works by binding to the abnormal CFTR protein and keeping its chloride channel open for longer, improving airway hydration and mucus clearance. It was the first therapy to target the underlying genetic defect in cystic fibrosis.

Yes, Ivacaftor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2010601. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16220172. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

هل تبحث عن معلومات ملائمة للمرضى؟

Ivacaftor على PillFYI

البنية

بيانات سريعة

الصيغة الجزيئية: C24H28N2O3
المرادفات: 4

روابط خارجية

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.