Larotrectinib

CHEMBL3889654 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

428.4 g/mol

LogP

1.7

Phase

4

A highly selective TRK inhibitor used to treat solid tumors with NTRK gene fusions, regardless of where in the body the cancer originated. It targets a specific genetic mutation driving tumor growth across multiple cancer types.

الوزن الجزيئي

428,4000 g/mol

LogP

1,70

TPSA

86,00 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1

InChI

InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

Molecular Formula

C21H22F2N6O2

HBD / HBA

2 / 7

الروابط القابلة للدوران

3

الذرات الثقيلة

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A highly selective TRK inhibitor used to treat solid tumors with NTRK gene fusions, regardless of where in the body the cancer originated. It targets a specific genetic mutation driving tumor growth across multiple cancer types.

Yes, Larotrectinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3889654. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 46188928. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C21H22F2N6O2
المرادفات: 1

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.